- Injecting oral formulations
- Crushing Oral formulations
- Taking drugs from family or friends
- Buying prescription medications from the street
- Multiple-doctoring
- Recurrent prescription losses
- Ongoing complaints about need to increase dose
- Asking for specific medication
- Dysphoria
- Myalgias
- Diarrhea
- Cravings
- Sweating
- Goosebumps
- Alcohol dependence
- Stimulant abuse
- Cannabinoids abuse
- Mood disorders resistant to treatment
- Anxiety disorders resistant to treatment
- Family and relationship problems
- Job loss and unemployment
- Concerns expressed by family or friends
- Resistance to dose reduction
- Reporting severe withdrawal symptoms with minor dose reduction
- Denying dependence
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