Causes of QTc prolongation
Clinical studies have found that the risk of QTc prolongation is higher among women with turner syndrome compared to women with no Turner syndrome.
Drugs that cause QTc prolongation
- Alfuzosin, Uroxatral®
- Amantadine, Symmetrel®
- Amiodarone, Cordarone®
- Amisulpride, Solian®
- Amitriptyline, Elavil®
- Amoxapine, Asendin®
- Anagrelide, Agrylin®
- Apomorphine, Apokyn®
- Aripiprazole, Abilify®
- Arsenic trioxide, Trisenox®
- Astemizole, (Off US mkt) Hismanal®
- Atazanavir, Reyataz®
- Azithromycin, Zithromax®
- Bedaquiline, Sirturo®
- Bepridil, Vascor®
- Bortezomib, Velcade®
- Bosutinib, Bosulif®
- Chloral hydrate, Aquachloral®
- Chloroquine, Aralen®
- Chlorpromazine, Thorazine®
- Ciprofloxacin, Cipro®
- Citalopram, Celexa®
- Clarithromycin, Biaxin®
- Clomipramine, Anafranil®
- Clozapine, Clozaril®
- Cocaine, Cocaine
- Crizotinib, Xalkori®
- Dabrafenib, Tafinlar®
- Dasatinib, Sprycel®
- Desipramine, Pertofrane®
- Dexmedetomidine, Precedex®
- Dihydroartemisinin+piperaquine, Eurartesim®
- Diphenhydramine, Benadryl®
- Disopyramide, Norpace®
- Dofetilide, Tikosyn®
- Dolasetron, Anzemet®
- Domperidone, Motilium®
- Doxepin, Sinequan®
- Dronedarone, Multaq®
- Droperidol, Inapsine®
- Eribulin, Halaven®
- Erythromycin, E.E.S.®
- Escitalopram, Cipralex®
- Famotidine, Pepcid®
- Felbamate, Felbatol®
- Fingolimod, Gilenya®
- Flecainide, Tambocor®
- Fluconazole, Diflucan®
- Fluoxetine, Prozac®
- Foscarnet, Foscavir®
- Fosphenytoin, Cerebyx®
- Furosemide, (Frusemide) Lasix®
- Galantamine, Reminyl®
- Gatifloxacin, (Off US mkt) Tequin®
- Gemifloxacin, Factive®
- Granisetron, Kytril®
- Halofantrine, Halfan®
- Haloperidol, Haldol® (US & UK)
- Hydrochlorothiazide, Apo-Hydro®
- Ibutilide, Corvert®
- Iloperidone, Fanapt®
- Imipramine, (melipramine) Tofranil®
- Indapamide, Lozol®
- Isradipine, Dynacirc®
- Itraconazole, Sporanox®
- Ivabradine, Procoralan®
- Ketoconazole, Nizoral®
- Lapatinib, Tykerb®
- Levofloxacin, Levaquin®
- Levomethadyl, Orlaam®
- Lithium, Eskalith®
- Mesoridazine, Serentil®
- Methadone, Dolophine®
- Metronidazole, Flagyl®
- Mifepristone, Korlym®
- Mirabegron, Myrbetriq®
- Mirtazapine, Remeron
- Moexipril/HCTZ, Uniretic®
- Moxifloxacin, Avelox®
- Nelfinavir, Viracept®
- Nicardipine, Cardene®
- Nilotinib, Tasigna®
- Norfloxacin, Noroxin®
- Nortriptyline, Pamelor®
- Ofloxacin, Floxin®
- Olanzapine, Zyprexa®
- Ondansetron, Zofran®
- Oxytocin, Pitocin®
- Paliperidone, Invega®
- Paroxetine, Paxil®
- Pasireotide, Signifor®
- Pazopanib, Votrient®
- Pentamidine, Pentam®
- Perflutren lipid microspheres, Definity® Pimozide Orap®
- Pipamperone, Dipiperon (E.U)
- Posaconazole, Noxafil®
- Probucol, Lorelco®
- Procainamide, Pronestyl®
- Promethazine, Phenergan®
- Protriptyline, Vivactil®
- Quetiapine, Seroquel®
- Quinidine, Quinaglute®
- Quinine sulfate, Qualaquin®
- Ranolazine, Ranexa®
- Rilpivirine, Edurant®
- Risperidone, Risperdal®
- Ritonavir, Norvir®
- Roxithromycin, Rulide®
- Saquinavir, Invirase®(combo)
- Sertindole, Serdolect®
- Sertraline, Zoloft®
- Sevoflurane, Ulane®
- Solifenacin, VESIcare®
- Sorafenib, Nexavar®
- Sotalol, Betapace®
- Sparfloxacin, Zagam®
- Sulpiride, Dogmatil®
- Sunitinib, Sutent®
- Tacrolimus, Prograf®
- Tamoxifen, Nolvadex®
- Telaprevir, Incivek®
- Telavancin, Vibativ®
- Telithromycin, Ketek®
- Terfenadine, Seldane®
- Tetrabenazine, Nitoman®
- Thioridazine, Mellaril®
- Tizanidine, Zanaflex®
- Tolterodine, Detrol®
- Toremifene, Fareston®
- Trazodone, Desyrel®
- Trimethoprim-Sulfa, Septra®
- Trimipramine, Surmontil®
- Vandetanib, Caprelsa®
- Vardenafil, Levitra®
- Vemurafenib, Zelboraf®
- Venlafaxine, Effexor®
- Voriconazole, VFend®
- Vorinostat, Zolinza®
- Ziprasidone, Geodon®
References
- Trolle, C., Mortensen, K. H., Pedersen, L. N., Berglund, A., Jensen, H. K., Andersen, N. H., & Gravholt, C. H. (2013). Long QT Interval in Turner Syndrome – A High Prevalence of LQTS Gene Mutations. PLoS ONE, 8(7), e69614. http://doi.org/10.1371/journal.pone.0069614