Steroids

Introduction

Anabolic Steroids are any drugs chemically related to testosterone, a male hormone that promotes muscle growth. There are more than 100 varieties of anabolic steroids but only a limited number have been approved for human use. Anabolic Steroids are Schedule III substances and require a prescription in order to be used medically in the United States.

Illicit steroid use is linked to athletic competitions and/or an athlete trying to gain a competitive edge. Some individuals may use steroids to alter their to increase their muscle mass.

Epidemiology

  • It has been estimated that 2.9 million to 4.0 million individuals in the United States, nearly all of whom are male, have used steroids at some time in their lives.
  • The same study estimated that about 1 million men in the United States have experienced steroid dependence.

Physical effects

  • Anabolic effects that include increases in muscle mass, the size of some internal organs, and calcium in the bones.
  • Androgenic effects, which include masculinizing effects like deepening of the voice, increased facial hair, and initial enlargement of some male sex glands.

Side effects

Short-term health effects: 

  • Acne
  • Fluid retention
  • Rapid weight gain
  • Increased blood pressure and cholesterol levels
  • Insomnia (inability to sleep)
  • Headaches
  • Reduced sexual functioning
  • Increase in muscle size
  • Swelling of feet and ankles
  • Improved healing
  • Improved appetite
  • Reduced sperm count
  • Damage to the heart
  • Impotence
  • Difficulty or pain while urinating
  • Breast reduction in women
  • Excessive hair growth

 

Long-term health effects:

  • Liver disease or liver cancer
  • Development of breasts
  • Shrinking of the testicles
  • Enlarged clitoris in women
  • Abnormal menstrual cycles in women
  • Blood clotting difficulties
  • Development of cholesterol patterns associated with coronary heart disease, obstructed blood vessels, or stroke
  • Heart attacks
  • Clotting disorders
  • Cardiovascular, liver, and reproductive organ damage
  • Premature heart attacks and strokes
  • Reduced sexual functioning
  • Stunted growth in adolescents
  • Increased chance of injuring ligaments, tendons and muscles
  • When injecting: bacterial infections, abscesses, cellulitis, and HIV/AIDS
  • Increase in muscle size

 Psychological Effects

  • Increase aggressiveness or lead them to become more violent
  • Extreme mood swings can also occur.
  • Depression is often seen when the drugs are stopped and may contribute to a dependence on anabolic steroids.
  • Paranoid jealousy, extreme irritability, delusions, and impaired judgment stemming from feelings of invincibility.
  • Steroid addiction and dependence

Signs and symptoms of steroid abuse

  • Very low body fat, extreme muscularity, disproportionately large upper torso
  • Acne on face, shoulders, back
  • Pigmented striae on skin
  • Excessive facial or body hair
  • Superficial confidence; feelings of invincibility or grandiosity
  • Restlessness
  • Anxiety
  • Frustration or excessive argumentativeness to the point of rage
  • Obsession with weight training, conditioning, body image, appearance
  • Dissatisfaction with appearance despite what others perceive
  • Extremely baggy or loose clothing

References

  • Kuhn, C., Swartzwelder, S., and Wilson, W. (1998). Buzzed: The Straight Facts About the Most Used and Abused Drugs from Alcohol to Ecstasy. New York: W.W. and Norton Company.
  • Kanayama, G., Cohane, B.A., Weiss, R.D., and Pope, H.G., Jr. Past anabolic-androgenic steroid use among men admitted for substance abuse treatment: An underrecognized problem? Journal of Clinical Psychiatry 64(2):156–160, 2003.
  • Grassley, C. The Abuse of Anabolic Steroids and Their Precursors by Adolescent and Amateur Athletes. Opening remarks to a hearing before the Senate Caucus on International Narcotics Control, July 13, 2004. drugcaucus.senate.gov/steroids04grassley.html
  • Volkow, N.D. Consequences of the Abuse of Anabolic Steroids—Before the Committee on Government Reform—United States House of Representatives: Statement for the Record, May 17, 2005. Bethesda, MD: National Institute on Drug Abuse. www.drugabuse.gov/testimony/3-17-05testimony.html
  • Johnston, L.D., O’Malley, P.M., Bachman, J.G., and Schulenberg, J.E. Monitoring the Future: National Results on Adolescent Drug Use—Overview of Key Findings, 2004. NIH Publication No. 05-5726. Bethesda, MD: National Institute on Drug Abuse, 2005, p. 4.
  • Brower, K.J. Anabolic steroid abuse and dependence. Current Psychiatry Report 4(5):377–387, 2002.
  • Pope, H.G., Jr., and Brower, K.J. Anabolic-androgenic steroids. In: Galanter, M., and Kleber, H.D., eds. The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 3d ed. Arlington, VA: American Psychiatric Publishing, Inc.,2004, pp. 301–309.
  • Thiblin  I, Garmo  H, Garle  M,  et al.  Anabolic steroids and cardiovascular risk: a national population-based cohort study. Drug Alcohol Depend. 2015;152:87-92.
  • Pope  HG  Jr, Wood  RI, Rogol  A, Nyberg  F, Bowers  L, Bhasin  S.  Adverse health consequences of performance-enhancing drugs: an Endocrine Society Scientific Statement. Endocr Rev. 2014;35(3):341-375.
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