Rabeprazole

Proton Pump Inhibitors (PPIs)

Pariet®

• Tablet 10 mg and 20 mg

• Potent proton pump inhibitor; suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump

• GERD: 20 mg once daily for 4 to 8 weeks up to 16 weeks
• Duodenal ulcer: 20 mg once daily before breakfast for 4 weeks
• Gastric ulcer: 20 mg po once daily for 4 to 6 weeks
• H. Pylori eradication: 20 mg twice daily, with Amoxy 1000 mg and Clarithromycin 500 mg twice daily for 7 days

• Hypersensitivity to rabeprazole or esomeprazole, lansoprazole, omeprazole, pantoprazole or any component of the formulation

May increase the risk of:

• Atrophic gastritis when used for long term
• Osteoporosis and bone fracture
• Hypomagnesemia

PPIs may reduce the therapeutic effect of clopidogrel through reduced formation of it’s  active metabolite

• PPIs may increase the serum concentration of Amphetamines
• PPIs may decrease the serum concentration of Atazanavir, indinavir, Itraconazole
• PPIs May increase the metabolism of CYP3A4 Substrates

• Category B
• Excretion in breast milk unknown

• Headache (2%-5%)
• Diarrhea (3%)
• Flatulence (3%)
• Constipation (2%)
• Nausea (2%)
• Electrolytes imbalance (<1%)
• Malaise (<1%)
• Flue like symptoms (<1%)
• QT Prolongation (<1%)
• Hemolytic anemia (<1%)
• Bradycarida (<1%)
• Abnormal vision (<1%)
• Arthralgia (<1%)
• Depression or delirium (<1%)
• May cause insomnia, anxiety, dizziness, nervousness, somnolence, vertigo, convulsions, abnormal dreams, agitation, amnesia, confusion, extrapyramidal syndrome